Anthropic is seeking a Staff Software Engineer for Applied AI, Science & Engineering to build reliable, scalable software that enables Claude to assist scientists and engineers across fields like energy, materials, hardware design, and other physical-world domains. This is an engineering role first: you will work closely with domain experts to understand problems, prototype quickly, and build and harden the systems that make the work repeatable. You will help Claude carry problems from literature review through hypothesis generation, simulation, analysis, and design iteration; connect scientific computing and simulation tools so Claude can drive them reliably and at scale; design evaluations to verify Claude’s results with clear honesty about limitations; and sit with scientists and engineers at partner organizations to learn their workflows and translate open-ended questions into well-specified, verifiable tasks, then ship pilots into their workflows and build reusable components from successful engagements. You will act as the technical voice on Claude’s performance in science and engineering and collaborate with research and product teams to guide future developments. You may be a good fit if you have 8+ years of software experience across the stack, have built real systems with large language models including agents, tool use, or evaluations, and have worked on technical problems in science or engineering fields such as physics, materials, chemistry, or electrical or mechanical engineering. Startup-like experience and the ability to work directly with expert users while
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Anthropic is seeking a Staff Software Engineer for Applied AI, Science & Engineering to build reliable, scalable software that enables Claude to assist scientists and engineers across fields like energy, materials, hardware design, and other physical-world domains. This is an engineering role first: you will work closely with domain experts to understand problems, prototype quickly, and build and harden the systems that make the work repeatable. You will help Claude carry problems from literature review through hypothesis generation, simulation, analysis, and design iteration; connect scientific computing and simulation tools so Claude can drive them reliably and at scale; design evaluations to verify Claude’s results with clear honesty about limitations; and sit with scientists and engineers at partner organizations to learn their workflows and translate open-ended questions into well-specified, verifiable tasks, then ship pilots into their workflows and build reusable components from successful engagements. You will act as the technical voice on Claude’s performance in science and engineering and collaborate with research and product teams to guide future developments. You may be a good fit if you have 8+ years of software experience across the stack, have built real systems with large language models including agents, tool use, or evaluations, and have worked on technical problems in science or engineering fields such as physics, materials, chemistry, or electrical or mechanical engineering. Startup-like experience and the ability to work directly with expert users while
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Based on: Staff Software Engineer
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11 active roles from this employer in the JobMatcher catalog.
Software Engineer, Core Product
Front
Software Engineer
Flai
Technical Program Manager III
Staff Software Engineer, AI Developer Tooling
Sentry
Software Engineer
OpenAI
Software Engineer - Enterprise Controls
OpenAI
Staff Software Engineer
Gusto
Staff Product Manager
The Trade Desk
Senior Software Engineer
Gallup
Recruiting Operations Program Manager
Baseten
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© 2026 JobMatcher. All rights reserved.